2010 (MMX) was a common year starting on Friday.
- The events of InFamous take place:
- Two weeks before the Empire City Blast, the events of InFamous: Post Blast occurred.
- The Empire City Blast occurred, resulting in thousands of deaths but the birth of a new conduit.
- The Empire City Quarantine went into effect, resulting in city-wide chaos.
- Cole MacGrath, now a hero to the people, discovered his past.
- The events of InFamous: DC Comics occurred.
- A month later, Cole met Lucy Kuo, who told him about Sebastian Wolfe and his research. They would not expand upon this until 2011.
- Joseph Bertrand III took control of the First Sons' assets in New Marais.
- Bertrand began transforming people into corrupted creatures and sending them to attack citizens, eventually overwhelming the New Marais Police. This led to the foundation of the Militia, and his takeover of the city.
- Rosco Laroche and his Rebels began a turf war against Bertrand and his Militia, winning their early battles. However, when the Militia received better weaponry and the corrupted got involved, the tide turned against the Rebels, forcing them to retreat into Ascension Parish.
- Trish Dailey
- Amy Dailey (Trish's sister)
- The Voice of Survival
- Moya Jones
- Darren Bridges
- Thousands of lives due to the Blast