The Empire City Quarantine, or simply The Quarantine, was a blockade created by the U.S Government in an effort to contain the deadly plague and biological hazards released into Empire City as a result of the Blast in the Historic District.
After the Empire City Blast, Empire City suffered from societal collapse and a deadly plague. As a result, the government erected the quarantine and barricaded Stampton Bridge of the Neon District to prevent anyone from entering or leaving the city. This barricade was reinforced with a large police force, turrets, and a literal wall of machine guns near the other side.
In an escape attempt, Cole MacGrath led a number of civilians through the barricade, almost reaching the other end. However, the small rebellion soon met their end, as they found that a wall of guns was erected as a defensive structure, and many civilians were either injured or killed. Zeke Dunbar managed to escape death by jumping off the bridge into the water, while Cole managed to escape death by jumping onto a separate platform where the FBI agent Moya Jones was expecting him.
The quarantine also included a blockade of the waters surrounding Empire City to keep boats from entering or exiting the city. The Dust Men attempted to challenge this blockade by sailing past in boats loaded with caged civilians. However, Cole was tasked with freeing the civilians when he was told that the quarantine blockade has been ordered to gun down any boats that would attempt to pass, regardless of any number of civilian casualties.
Near the beginning of Infamous 2, the quarantine had finally been lifted, but it seemed most people have stayed, thanks to the efforts of Cole MacGrath and the Empire City Police Department eliminating all the gangs and restoring peace to the city.
- The quarantine caused a massive shortage of goods and services in Empire City. Commodities could only be obtained through paying high prices, receiving government airdrops or stealing. An example of the quarantine's effects included gasoline sold at around $9 for a gallon.
- The Empire City Quarantine and the negative effects it had on the city bears some resemblance to the situation depicted in the DC Comics story line Batman: No Mans Land. Sucker Punch has stated that No Mans Land, as well as the graphic novel DMZ, were one of the many sources of inspiration for designing the game's environment.