List of Factions in Infamous
- Main article: Reapers
- Main article: Dust Men
- Main article: First Sons
The final faction that Cole faces. The First Sons are a cult group dedicated to discovering and unlocking the potential of humans. They can be traced back all the way to the 17th century. They control the Historic District of Empire City with their leader Kessler. Also unlike the other factions of Empire City they are fully equipped with the latest in weaponry and armor, making them the toughest of the three factions. The First Sons wear three piece suits and gas masks with attached tanks.
Empire City Police
- Main article: Empire City Police
The police force of Empire City, they are located in all three districts, with their most prominent member being Warden Harms. As Cole fends off most of the other factions, Cole is either able to gain help from the police force (Good Karma), or they become another hostile faction to him (Evil Karma).
List of Factions in Infamous 2
- Main article: The Militia
The Militia is the first hostile faction that Cole encounters in inFamous 2, led by Joseph Bertrand III. Unlike the other factions, the Militia have no Conduits in their ranks. This is because they are a strict anti-conduit group and extremely violent enforcers. Their colors are orange and gray. Mini-gunners are the most noteworthy types.
- Main article: Vermaak 88
The Vermaak 88, or the so-called Forced Conduits, are a faction clad in metal armor, possessing cryogenic abilities. Little is known, but they were originally created by The Militia, and are the only faction to only feature Conduits. They're clad in metal armor along with some leather apparel, and use firearms similar to other factions. The Crushers are one of the more notable types of the faction.
- Main article: Corrupted
The Corrupted are mutated citizens of New Marais created by Bertrand. Their only purpose is to wreak havoc and mayhem all across New Marais. They have no normal human infantry, nor conduits. Larger forms include Devourers and Bertrand in his Behemoth form. They are hostile towards all factions as well as Cole.
- Main article: The Rebels
The Rebels are a group working against the Militia by protesting and trying to drive them out of town. They are one of the factions that don't consist of Conduits, and cooperate with Cole. Cole first stumbles into them when rescuing Rosco Laroche's niece Sara in The Sacrifice.
New Marais Police Department
- Main article: New Marais Police Department
This group is the police force of New Marais that form the protection of the city's citizens. As Cole fends off most of the other factions, he is either able to receive help from the police force (Good Karma), or gain another hostile faction (Evil Karma). The NMPD is also a human faction, like the police department in Empire City, the Rebels and the Militia. Their leader is unknown and there are only two types of officers. They are usually seen patrolling around the streets at random locations.
- Main article: Vampires
The Vampires are first introduced in the Festival of Blood Stand-Alone Downloadable game set during the events of inFamous 2. They're the only gang within the series that have both male and female members. They are all under the lead of Bloody Mary and it's Cole's mission to exterminate them. The Vampires are not part of the inFamous series' canon.
- At one point in time each Empire City Faction Leader (excluding Warden Harms) was a member of the First Sons.
- Sasha is the first, and only female leader in the series, until Second Son, with Brooke Augustine - apart from Bloody Mary, who is not part of the canon - as well as the only leader not seen outside of her fight scene. Though ironically, if one plays the InFamous road, she has the most interaction with him, more than any other leader.
- Both Alden and Sasha hate Kessler, as well as were driven insane because of him. In a Dead Drop message, John mentions that Sasha met with Alden back when she was still a member of the First Sons, for what is never explained.
- None of the faction's members (excluding the Empire City Police, New Marais Police and The Corrupted) faces were ever seen: The Reapers are hidden by their hoods, Dust Men wear bags over their heads, the First Sons wear gas masks, the Militia wear hockey masks or covers it with something else and the Vermaak 88 wear helmets (excluding the Crushers and Ice Titans), although part of a Reaper's face was seen in a concept art/wallpaper and on Cole's Reaper Skin, and a Vermaak 88 conduit's face was also seen in the Rescue Kuo cutscene.
- The Dust Men never speak words, only uttering growls and grunts. It is never explained why they are unable to speak.
- In InFamous 2, every faction has at least one member that at one point is an ally of Cole, whether it be the Ice Gang Ally, Nix's Corrupted or near the very end of InFamous 2, The Militia.
- Festival of Blood is the first game that has female and male gangsters fighting against Cole.
- The gangs in inFAMOUS is similar to that of the original Sly Cooper, in which they're separate, however work together to try and keep Sly from his goal, this is also true for the sequel, as all the gangs are controlled by Joseph Bertrand.