Situated in the southwest of the Neon District, it was a large wharf, which served as storage for shipping crates. It was easily identifiable with the large neon sign over the southern alley.
Fisherman's Wharf was one of the areas within the district that was briefly powered down. After power was restored to this area, it became the central focus point for the mission, "Trish Reaches Out," where Cole MacGrath had to defend a crate full of medical supplies from a Reaper assault.
Fisherman's Wharf was featured once again, as Cole was heading to a boat there when the Beast destroyed Empire City.
There are several Blast Shards in the area, one on top of the neon sign.
- In real life, Fisherman's Wharf is a neighborhood and popular tourist destination in San Francisco, California.