The game mostly received positive reviews from critics. IGN's Greg Miller considered the title to be "one of the best PlayStation 3 games to date". Brad Shoemaker from Giant Bomb believed that Sucker Punch did a good job with the basic gameplay elements, tying together all of the various aspects. Critics also praised the combination of Cole's powers with the game's karma elements,, as well as the structure of the game's missions, claiming them to be a strong asset and even citing them as positive aspects of the game.
Reviewers commented positively about the setting of Empire City, as it contributed significantly to the success of the game. While the climbing and platforming gameplay were mostly praised for being well done, some pointed out that how difficult it is trying to fine-tune Cole's jumps, as his climbing was deemed to touchy, and the character would grab onto ledges too greedily.
Upon its release in May 2009, the game has managed to sell 175,900 copies in the United States during its first week. The game has sold nearly two million copies by June 2010, according to Game Informer. Infamous was awarded for Best Story by IGN and Best Acting at the 2009 Golden Game Awards, along with four addition nominations for the latter, such as Best PlayStation 3 Game, Best Graphics, Best Independent Game, and Studio of the Year. In late 2010, Infamous ranked fifth on IGN's "The Top 25 PlayStation 3 Games".
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